SARI
Medical abbreviation · Drug Class
| Stands for | Serotonin antagonist and reuptake inhibitor |
|---|---|
| Categories | Medical |
SARI stands for Serotonin antagonist and reuptake inhibitor, a drug class abbreviation.
Antidepressant class that includes trazodone and nefazodone, which block 5-HT2A receptors and weakly inhibit serotonin reuptake. Trazodone is far more often prescribed at low doses for insomnia than for depression.
Example: Trazodone (SARI) 50 mg at bedtime PRN sleep; caution orthostasis.
Usage notes
Trazodone can rarely cause priapism, a prolonged erection that is a medical emergency. Nefazodone carries a boxed warning for liver failure, and the original brand, Serzone, was withdrawn in the US in 2004, although generics remain. Evidence for trazodone in insomnia is limited despite its popularity.
Related abbreviations
More drug class abbreviations
- PDE5i – Phosphodiesterase-5 inhibitor
- PGA – Prostaglandin analog
- PI – Protease inhibitor
- PPI – Proton pump inhibitor
- SABA – Short-acting beta2-agonist
- SAMA – Short-acting muscarinic antagonist
- SARMs – Selective androgen receptor modulators
- SCIT – Subcutaneous immunotherapy
- SERD – Selective estrogen receptor degrader
- SERM – Selective estrogen receptor modulator
- SGA – Second-generation antipsychotic
- SGLT2i – Sodium-glucose cotransporter 2 inhibitor
See all 113 drug class abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.