SNV

Science & Engineering abbreviation · Genetics

SNV
Stands forSingle-nucleotide variant
CategoriesScience & Engineering

SNV stands for Single-nucleotide variant, a genetics abbreviation.

Change of a single DNA letter at a particular position, regardless of how common it is in the population. In clinical and cancer sequencing reports, SNVs include rare inherited variants and new mutations acquired by tumors.

Example: Tumor sequencing identified 42 somatic SNVs, including a known hotspot mutation in KRAS.

Usage notes

SNV is the more neutral term preferred in clinical genomics, since "polymorphism" implies a common variant. SNVs are classified by effect as synonymous (no amino acid change), missense (a different amino acid) or nonsense (a premature stop codon).

More genetics abbreviations

  • scRNA-seq – Single-cell RNA sequencing
  • sgRNA – Single guide RNA
  • shRNA – Short hairpin RNA
  • siRNA – Small interfering RNA
  • SNP – Single-nucleotide polymorphism
  • snRNA – Small nuclear RNA
  • ssDNA – Single-stranded DNA
  • STR – Short tandem repeat
  • T2T – Telomere-to-telomere
  • TF – Transcription factor
  • UTR – Untranslated region
  • VNTR – Variable number tandem repeat

See all 57 genetics abbreviations →

Edited by the AbbreviationList.com team. Spotted an error or a missing meaning? Contact us.