EPCS

Medical abbreviation · Prescription

EPCS
Stands forElectronic prescribing of controlled substances
CategoriesMedical

EPCS stands for Electronic prescribing of controlled substances, a prescription abbreviation.

E-prescribing of Schedule II to V drugs, which requires DEA-compliant software, identity proofing and two-factor authentication each time the prescriber signs. It became mandatory for controlled drugs under Medicare Part D, with CMS enforcing compliance from 2023.

Example: EPCS token expired, so the clinic had to re-verify Dr. Lee's identity before sending the oxycodone script.

Usage notes

The DEA first allowed EPCS through an interim final rule in 2010. The federal requirement for Part D came from the 2018 SUPPORT Act, and many states mandate EPCS for all payers. EPCS improves security against forged and altered opioid prescriptions.

More prescription abbreviations

  • cc – Cubic centimeter
  • c̄ – Cum (with)
  • D/C – Discontinue
  • DAW – Dispense as written
  • Disp – Dispense
  • dtd – Dentur tales doses (give such doses)
  • eRx – Electronic prescription
  • gr – Grain
  • gtt/min – Drops per minute
  • HS – Hora somni (at bedtime)
  • IU – International unit
  • LD – Loading dose

See all 77 prescription abbreviations →

This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.