ARNI

Medical abbreviation · Drug Class

ARNI stands for Angiotensin receptor-neprilysin inhibitor, a drug class abbreviation.

Heart failure drug class combining an ARB with a neprilysin inhibitor; the only member is sacubitril/valsartan (Entresto). Blocking neprilysin raises natriuretic peptides that promote sodium excretion and relax blood vessels.

Example: Stop lisinopril, wait 36 hours, then start ARNI 24/26 mg BID.

Usage notes

The PARADIGM-HF trial (2014) found sacubitril/valsartan reduced cardiovascular death or heart failure hospitalization by about 20 percent compared with enalapril, leading to FDA approval in 2015. A 36-hour gap is required after stopping an ACE inhibitor because combining them sharply increases angioedema risk.

Related abbreviations

More drug class abbreviations

• ADC – Antibody-drug conjugate
• AED – Antiepileptic drug
• AG – Aminoglycoside
• AGI – Alpha-glucosidase inhibitor
• AI – Aromatase inhibitor
• ARB – Angiotensin II receptor blocker
• ASM – Antiseizure medication
• ASO – Antisense oligonucleotide
• ATD – Antithyroid drug
• BAS – Bile acid sequestrant
• BB – Beta-blocker
• BiTE – Bispecific T-cell engager

See all 113 drug class abbreviations →

Edited by the AbbreviationList.com team. Spotted an error or a missing meaning? Contact us.

This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.