Hyper-CVAD
Medical abbreviation · Hematology and Oncology
| Stands for | Hyperfractionated cyclophosphamide, vincristine, Adriamycin (doxorubicin), dexamethasone |
|---|---|
| Categories | Medical |
Hyper-CVAD stands for Hyperfractionated cyclophosphamide, vincristine, Adriamycin (doxorubicin), dexamethasone, a hematology and oncology abbreviation.
Intensive chemotherapy regimen for adult acute lymphoblastic leukemia, Burkitt lymphoma and some mantle cell lymphomas, alternating course A (Hyper-CVAD) with course B (high-dose methotrexate and cytarabine) for a total of eight courses.
Example: Ph-positive ALL: Hyper-CVAD alternating with methotrexate-cytarabine, plus ponatinib.
Usage notes
Developed at MD Anderson Cancer Center, with results published by Hagop Kantarjian and colleagues in 2000. "Hyperfractionated" means cyclophosphamide is given in several divided doses over three days to intensify cell kill. The regimen requires hospital admission for some courses, growth factor support and central nervous system prophylaxis with intrathecal chemotherapy.
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This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.