dsDNA
Abbreviation with 2 meanings
| Stands for | Anti-double-stranded DNA antibody |
|---|---|
| Meanings | 2 |
| Categories | Medical, Science & Engineering |
dsDNA has two meanings. It stands for Anti-double-stranded DNA antibody (laboratory test) or Double-stranded DNA (genetics).
Meanings of dsDNA at a glance
| # | dsDNA stands for | Context |
|---|---|---|
| 1 | Anti-double-stranded DNA antibody | Medical › Laboratory Test |
| 2 | Double-stranded DNA | Science & Engineering › Genetics |
1. Anti-double-stranded DNA antibody
Medical · Laboratory Test Abbreviations
Autoantibody highly specific for systemic lupus erythematosus, positive in roughly 60 to 70 percent of people with the disease. Rising levels, especially with falling complement C3 and C4, often signal a flare and are associated with lupus nephritis.
Example: dsDNA up to 340 IU/mL with low C3; urine protein ordered to screen for nephritis.
Methods include ELISA, the Crithidia luciliae immunofluorescence test and the older, very specific Farr radioimmunoassay, and results are not interchangeable between methods. Drug-induced lupus from hydralazine or procainamide usually produces anti-histone rather than anti-dsDNA antibodies, a useful distinction. Often written anti-dsDNA.
2. Double-stranded DNA
Science & Engineering · Genetics Abbreviations
DNA in its usual form of two complementary strands paired into a double helix. Lab protocols specify dsDNA when measuring DNA concentration, describing virus genomes or testing for autoimmune antibodies.
Example: Quantify the library with a dsDNA-specific fluorescent assay rather than UV absorbance.
Many viruses, such as herpesviruses and adenoviruses, have dsDNA genomes. Antibodies against dsDNA are a characteristic laboratory finding in systemic lupus erythematosus. At an absorbance of 1.0 at 260 nm, a solution contains about 50 nanograms per microliter of dsDNA.
Related abbreviations
More laboratory test abbreviations
- CRP – C-reactive protein
- CSF – Cerebrospinal fluid
- DAT – Direct antiglobulin test
- DBili – Direct bilirubin
- EDTA – Ethylenediaminetetraacetic acid
- eGFR – Estimated glomerular filtration rate
- ELISA – Enzyme-linked immunosorbent assay
- ESR – Erythrocyte sedimentation rate
See all 135 laboratory test abbreviations →
More genetics abbreviations
- ChIP-seq – Chromatin immunoprecipitation sequencing
- cM – Centimorgan
- CNV – Copy-number variation
- CpG – Cytosine-phosphate-guanine (site)
- eQTL – Expression quantitative trait locus
- FISH – Fluorescence in situ hybridization
- GC – Guanine-cytosine (content)
- gDNA – Genomic DNA
See all 57 genetics abbreviations →
This entry is for general education and is not medical advice. Abbreviation use varies between institutions; always confirm in context.